Influence of reduced centrifugation time on clinical chemistry analytes and literature review

Abstract Objectives Centrifugation is a time-consuming step which increases the turnaround time (TAT) in laboratories. A few studies have addressed effect of altering centrifugation settings on analytical quality for clinical chemistry analytes, and most these used collection tubes with gel separators. However, separator may be unsuitable some laboratories because they are slightly more expensive than without separators not appropriate special tests. The aim this study was to investigate conditions analytes. Methods We compared times 7 min at 2,200× g 5 2,750× manufacturer’s protocol 10 1,300× as reference condition. Twenty general analytes were studied lithium heparin plasma Results For all except carbon dioxide (CO 2 ), no significant differences analyte results observed when reduced. Deming regression Bland–Altman plots demonstrated an acceptable concordance within limits total allowable error between two rapid Conclusions Our confirmed that alternate either or samples collected data support using higher speeds shorter improve TAT results.